Van de Ven Double Ends Everton's Run at Brand New Stadium
The Dutch defender emerged as the first backline player to score two goals in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
At a glance
The Spurs defender nods home twice in first half
Everton's defender has goal ruled after VAR review
Senegalese midfielder nets third in dying moments
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham extended their winning streak in away games in the Premier League and delivered Everton their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven struck twice from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to turn it around before Pape Matar Sarr - assisted by former Toffees attacker Richarlison - headed home a third to seal the victory.
The Everton defender believed he had equalized the scores five minutes after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an set-piece.
Beto, in the meantime, missed a handful of opportunities, while Vicario made a succession of fine stops to ensure Tottenham went five matches on the road unbeaten in the English top flight.
But the VAR stepped in, instructing the match official to review the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side up to third in the Premier League, a handful of points off local foes and table-toppers Arsenal.
The Merseyside club remain in 14th position and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven excels in duties at both ends of the field
Following a drab weekday display in the European competition against the French side, where they mustered a only attempts on target, the manager chose Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to make much of an impact before being substituted for the substitute after 60 minutes on the field, but it emerged he wasn't needed in the end.
Centre-back Van de Ven converted into an attacking force to be feared.
Tottenham's opening strike came from a well-worked corner routine, with Rodrigo Bentancur directing the ball toward the face of goal for an unmarked the defender to head home.
And Ven de Ven - filling in as skipper in the Argentine's absence - added his next goal in added time as he rose above the England keeper to nod in.
The Dutchman was equally outstanding in defensive duties, combining effectively with Kevin Danso as the pair handled superbly with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees lacking finishing touch
Everton's new home had been a happy hunting ground, but it appears the novelty may have faded slightly and supporters flocked to the exits after Sarr's third for Spurs.
The break in the team's winning streak at home will not be a massive worry for David Moyes, but their striker situation are.
The forward and Thierno Barry - the Everton's pair of established strikers - had netted only a single goal combined before Sunday's match.
And they were unable to contribute to that poor tally on a wet and gloomy evening on Merseyside.
The striker's form was epitomized when he opted to bicycle-kick a clear chance from close range, despite having space and opportunity to readjust for a more conventional attempt that would have tested the keeper.
Barry, as well, failed to make an impact after coming on for the starter in the second half.
It was not for a shortage of chance. Most of Everton's attacks came through Grealish and the forward, who relentlessly delivered dangerous balls into the Spurs penalty area.
Upcoming fixtures for these two sides?
Everton: The team travel to Sunderland in the top flight on early November at 8 PM.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.